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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50421929
Substrate
n/a
Meas. Tech.
ChEBML_201733
IC50
2.2±n/a nM
Citation
 Russell, MG; Baker, R; Billington, DC; Knight, AK; Middlemiss, DN; Noble, AJ Benz[f]isoquinoline analogues as high-affinity sigma ligands. J Med Chem 35:2025-33 (1992) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50421929
Synonyms:
CHEMBL544987
Type:
Small organic molecule
Emp. Form.:
C23H31N
Mol. Mass.:
321.4989
SMILES:
C1CN(C[C@@H]2CCc3ccccc3[C@H]12)C1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 |r,wU:19.27,21.25,wD:4.3,13.13,15.28,17.26,TLB:22:21:23:17.16.18,22:17:23:14.21.20,THB:2:14:23:17.16.18,(4.25,1.05,;2.97,.26,;1.6,1.04,;1.59,2.58,;2.93,3.36,;2.92,4.88,;4.24,5.64,;5.62,4.85,;6.9,5.66,;8.23,4.9,;8.24,3.34,;6.9,2.58,;5.57,3.35,;4.3,2.57,;.23,.31,;.24,-1.24,;-1.09,-1.63,;-2.6,-1.09,;-3.75,-2.4,;-2.14,-1.95,;-2.14,-.19,;-1.09,.98,;-2.6,.37,;-.78,-2.5,)|
Structure:
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