Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50423968
Substrate
n/a
Meas. Tech.
ChEMBL_935576 (CHEMBL2320112)
EC50
640±n/a nM
Citation
 Le, UMelancon, BJBridges, TMVinson, PNUtley, TJLamsal, ARodriguez, ALVenable, DSheffler, DJJones, CKBlobaum, ALWood, MRDaniels, JSConn, PJNiswender, CMLindsley, CWHopkins, CR Discovery of a selective M4 positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia. Bioorg Med Chem Lett 23:346-50 (2012) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_RAT | Cholinergic, muscarinic M2 | Chrm-2 | Chrm2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51555.53
Organism:
RAT
Description:
P10980
Residue:
466
Sequence:
MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50423968
Synonyms:
CHEMBL2313377
Type:
Small organic molecule
Emp. Form.:
C13H14ClN3OS
Mol. Mass.:
295.788
SMILES:
Cc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl
Structure:
Search PDB for entries with ligand similarity: