Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 2
Ligand
BDBM50424005
Substrate
n/a
Meas. Tech.
ChEMBL_935891 (CHEMBL2318189)
IC50
23±n/a nM
Citation
 Cai, C; Kang, FA; Hou, C; O'Neill, JC; Opas, E; McKenney, S; Johnson, D; Sui, Z Novel 2-aminooctahydrocyclopentalene-3a-carboxamides as potent CCR2 antagonists. Bioorg Med Chem Lett 23:351-4 (2012) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Homo sapiens (Human)
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
  
Inhibitor
Name:
BDBM50424005
Synonyms:
CHEMBL2313770
Type:
Small organic molecule
Emp. Form.:
C24H31F4N3O3
Mol. Mass.:
485.5149
SMILES:
COC1COCCC1N[C@@H]1C[C@H]2C[C@H](F)C[C@]2(C1)C(=O)N1CCc2ncc(cc2C1)C(F)(F)F |r|
Structure:
Search PDB for entries with ligand similarity: