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Target
Acetolactate synthase catalytic subunit, mitochondrial
Ligand
BDBM50424587
Substrate
n/a
Meas. Tech.
ChEMBL_934102 (CHEMBL2318855)
Ki
346±n/a nM
Citation
 Lee, YT; Cui, CJ; Chow, EW; Pue, N; Lonhienne, T; Wang, JG; Fraser, JA; Guddat, LW Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase. J Med Chem 56:210-9 (2013) [PubMed]  Article 
Target
Name:
Acetolactate synthase catalytic subunit, mitochondrial
Synonyms:
ILV2 | ILVB_YEAST | SMR1
Type:
PROTEIN
Mol. Mass.:
74947.98
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_934102
Residue:
687
Sequence:
MIRQSTLKNFAIKRCFQHIAYRNTPAMRSVALAQRFYSSSSRYYSASPLPASKRPEPAPSFNVDPLEQPAEPSKLAKKLRAEPDMDTSFVGLTGGQIFNEMMSRQNVDTVFGYPGGAILPVYDAIHNSDKFNFVLPKHEQGAGHMAEGYARASGKPGVVLVTSGPGATNVVTPMADAFADGIPMVVFTGQVPTSAIGTDAFQEADVVGISRSCTKWNVMVKSVEELPLRINEAFEIATSGRPGPVLVDLPKDVTAAILRNPIPTKTTLPSNALNQLTSRAQDEFVMQSINKAADLINLAKKPVLYVGAGILNHADGPRLLKELSDRAQIPVTTTLQGLGSFDQEDPKSLDMLGMHGCATANLAVQNADLIIAVGARFDDRVTGNISKFAPEARRAAAEGRGGIIHFEVSPKNINKVVQTQIAVEGDATTNLGKMMSKIFPVKERSEWFAQINKWKKEYPYAYMEETPGSKIKPQTVIKKLSKVANDTGRHVIVTTGVGQHQMWAAQHWTWRNPHTFITSGGLGTMGYGLPAAIGAQVAKPESLVIDIDGDASFNMTLTELSSAVQAGTPVKILILNNEEQGMVTQWQSLFYEHRYSHTHQLNPDFIKLAEAMGLKGLRVKKQEELDAKLKEFVSTKGPVLLEVEVDKKVPVLPMVAGGSGLDEFINFDPEVERQQTELRHKRTGGKH
  
Inhibitor
Name:
BDBM50424587
Synonyms:
CHEMBL1885280 | Ethametsulfuron Methyl
Type:
Small organic molecule
Emp. Form.:
C15H18N6O6S
Mol. Mass.:
410.405
SMILES:
CCOc1nc(NC)nc(NC(=O)NS(=O)(=O)c2ccccc2C(=O)OC)n1
Structure:
Search PDB for entries with ligand similarity: