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TargetAcetolactate synthase catalytic subunit, mitochondrial
LigandBDBM50424589
Substrate/Competitorn/a
Meas. Tech.ChEMBL_934102
Ki 127±n/a nM
Citation Lee, YTCui, CJChow, EWPue, NLonhienne, TWang, JGFraser, JAGuddat, LW Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase. J Med Chem56:210-9 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Acetolactate synthase catalytic subunit, mitochondrial
Name:Acetolactate synthase catalytic subunit, mitochondrial
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:74947.98
Organism:Saccharomyces cerevisiae
Description:ChEMBL_934102
Residue:687
Sequence:
MIRQSTLKNFAIKRCFQHIAYRNTPAMRSVALAQRFYSSSSRYYSASPLPASKRPEPAPS
FNVDPLEQPAEPSKLAKKLRAEPDMDTSFVGLTGGQIFNEMMSRQNVDTVFGYPGGAILP
VYDAIHNSDKFNFVLPKHEQGAGHMAEGYARASGKPGVVLVTSGPGATNVVTPMADAFAD
GIPMVVFTGQVPTSAIGTDAFQEADVVGISRSCTKWNVMVKSVEELPLRINEAFEIATSG
RPGPVLVDLPKDVTAAILRNPIPTKTTLPSNALNQLTSRAQDEFVMQSINKAADLINLAK
KPVLYVGAGILNHADGPRLLKELSDRAQIPVTTTLQGLGSFDQEDPKSLDMLGMHGCATA
NLAVQNADLIIAVGARFDDRVTGNISKFAPEARRAAAEGRGGIIHFEVSPKNINKVVQTQ
IAVEGDATTNLGKMMSKIFPVKERSEWFAQINKWKKEYPYAYMEETPGSKIKPQTVIKKL
SKVANDTGRHVIVTTGVGQHQMWAAQHWTWRNPHTFITSGGLGTMGYGLPAAIGAQVAKP
ESLVIDIDGDASFNMTLTELSSAVQAGTPVKILILNNEEQGMVTQWQSLFYEHRYSHTHQ
LNPDFIKLAEAMGLKGLRVKKQEELDAKLKEFVSTKGPVLLEVEVDKKVPVLPMVAGGSG
LDEFINFDPEVERQQTELRHKRTGGKH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50424589
NameBDBM50424589
Synonyms:CHEMBL1229721 | DNDI1246776
TypeSmall organic molecule
Emp. Form.C12H12ClN5O4S
Mol. Mass.357.773
SMILESCOc1nc(C)nc(NC(=O)NS(=O)(=O)c2ccccc2Cl)n1
Structure
n/a