Target
Leukotriene A-4 hydrolase
Ligand
BDBM50425153
Substrate
n/a
Meas. Tech.
ChEMBL_936852 (CHEMBL2320734)
IC50
91±n/a nM
Citation
 Eccles, WBlevitt, JMBooker, JNChrovian, CCCrawford, Sde Leon, ARDeng, XFourie, AMGrice, CAHerman, KKarlsson, LKearney, AMLee-Dutra, ALiang, JLuna, RPippel, DRao, NRiley, JPSantillán, ASavall, BTanis, VMXue, XYoung, AL Identification of benzofuran central cores for the inhibition of leukotriene A(4) hydrolase. Bioorg Med Chem Lett 23:811-5 (2013) [PubMed]  Article 
Target
Name:
Leukotriene A-4 hydrolase
Synonyms:
LKHA4_MOUSE | Leukotriene A4 hydrolase | Lta4h
Type:
PROTEIN
Mol. Mass.:
69048.58
Organism:
Mus musculus
Description:
ChEMBL_936852
Residue:
611
Sequence:
MPEVADTCSLASPASVCRTQHLHLRCSVDFARRTLTGTAALTVQSQEENLRSLTLDTKDLTIEKVVINGQEVKYTLGESQGYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKQHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAPDPEDPSRKIYRFNQRVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSANEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQNTIKTFGESHPFTKLVVDLKDVDPDVAYSSIPYEKGFALLFYLEQLLGGPEVFLGFLKAYVKKFSYQSVTTDDWKSFLYSHFKDKVDLLNQVDWNTWLYAPGLPPVKPNYDVTLTNACIALSQRWVTAKEEDLSSFSIADLKDLSSHQLNEFLAQVLQKAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVHTYQEHKASMHPVTAMLVGRDLKVD
  
Inhibitor
Name:
BDBM50425153
Synonyms:
CHEMBL2313561
Type:
Small organic molecule
Emp. Form.:
C20H19N3O2S
Mol. Mass.:
365.449
SMILES:
C(N1CCCCC1)c1cc2cc(Oc3nc4ncccc4s3)ccc2o1
Structure:
Search PDB for entries with ligand similarity: