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Target
Acid-sensing ion channel 3
Ligand
BDBM50157090
Substrate
n/a
Meas. Tech.
ChEMBL_938637 (CHEMBL2327257)
IC50
9500±n/a nM
Citation
 Bagal, SK; Brown, AD; Cox, PJ; Omoto, K; Owen, RM; Pryde, DC; Sidders, B; Skerratt, SE; Stevens, EB; Storer, RI; Swain, NA Ion channels as therapeutic targets: a drug discovery perspective. J Med Chem 56:593-624 (2013) [PubMed]  Article 
Target
Name:
Acid-sensing ion channel 3
Synonyms:
ASIC3_RAT | Accn3 | Amiloride-sensitive cation channel 3 | Asic3 | Drasic
Type:
PROTEIN
Mol. Mass.:
59229.99
Organism:
Rattus norvegicus
Description:
ChEMBL_938637
Residue:
533
Sequence:
MKPRSGLEEAQRRQASDIRVFASSCTMHGLGHIFGPGGLTLRRGLWATAVLLSLAAFLYQVAERVRYYGEFHHKTTLDERESHQLTFPAVTLCNINPLRRSRLTPNDLHWAGTALLGLDPAEHAAYLRALGQPPAPPGFMPSPTFDMAQLYARAGHSLEDMLLDCRYRGQPCGPENFTVIFTRMGQCYTFNSGAHGAELLTTPKGGAGNGLEIMLDVQQEEYLPIWKDMEETPFEVGIRVQIHSQDEPPAIDQLGFGAAPGHQTFVSCQQQQLSFLPPPWGDCNTASLDPDDFDPEPSDPLGSPRPRPSPPYSLIGCRLACESRYVARKCGCRMMHMPGNSPVCSPQQYKDCASPALDAMLRKDTCVCPNPCATTRYAKELSMVRIPSRASARYLARKYNRSESYITENVLVLDIFFEALNYEAVEQKAAYEVSELLGDIGGQMGLFIGASLLTILEILDYLCEVFQDRVLGYFWNRRSAQKRSGNTLLQEELNGHRTHVPHLSLGPRPPTTPCAVTKTLSASHRTCYLVTRL
  
Inhibitor
Name:
BDBM50157090
Synonyms:
6-(2-(1-isopropyl-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)cyclopropyl)-2-naphthimidamide | 6-[2-(1-Isopropyl-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-yl)-cyclopropyl]-naphthalene-2-carboxamidine | CHEMBL185515
Type:
Small organic molecule
Emp. Form.:
C27H31N3
Mol. Mass.:
397.5551
SMILES:
CC(C)C1N(C)CCc2ccc(cc12)C1CC1c1ccc2cc(ccc2c1)C(N)=N
Structure:
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