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Target
Insulin-degrading enzyme
Ligand
BDBM50427696
Substrate
n/a
Meas. Tech.
ChEMBL_941898 (CHEMBL2329964)
Ki
70±n/a nM
Citation
 Abdul-Hay, SO; Lane, AL; Caulfield, TR; Claussin, C; Bertrand, J; Masson, A; Choudhry, S; Fauq, AH; Maharvi, GM; Leissring, MA Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity. J Med Chem 56:2246-55 (2013) [PubMed]  Article 
Target
Name:
Insulin-degrading enzyme
Synonyms:
Abeta-degrading protease | Human Insulin Degrading Enzyme (hIDE) | IDE | IDE_HUMAN | Insulin degrading enzyme (hIDE) | Insulin protease | Insulin-degrading enzyme | Insulinase | Insulysin | insulin-degrading enzyme isoform 1 precursor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
117968.59
Organism:
Homo sapiens (Human)
Description:
P14735
Residue:
1019
Sequence:
MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
  
Inhibitor
Name:
BDBM50427696
Synonyms:
CHEMBL2324201
Type:
Small organic molecule
Emp. Form.:
C37H45N9O9
Mol. Mass.:
759.8081
SMILES:
NC(N)=NCCC[C@H](NC(=O)[C@H](Cc1ccc2ccccc2c1)[C@H](O)C(=O)NO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(N)=O |r,wU:7.7,46.49,11.10,wD:32.33,23.25,(13.82,-27.05,;15.18,-27.77,;16.48,-26.94,;15.24,-29.3,;13.95,-30.13,;14.02,-31.67,;12.72,-32.49,;12.79,-34.03,;11.5,-34.86,;10.17,-34.09,;10.17,-32.55,;8.83,-34.87,;7.53,-34.09,;7.5,-32.55,;6.14,-31.8,;6.11,-30.26,;7.43,-29.47,;7.4,-27.93,;8.71,-27.13,;10.07,-27.87,;10.11,-29.41,;8.78,-30.21,;8.82,-31.75,;8.83,-36.41,;10.16,-37.18,;7.49,-37.17,;6.16,-36.41,;7.49,-38.72,;6.16,-39.49,;14.16,-34.74,;14.22,-36.28,;15.45,-33.91,;16.82,-34.62,;16.89,-36.16,;18.25,-36.87,;19.71,-36.36,;20.64,-37.59,;19.75,-38.85,;20.1,-40.35,;18.98,-41.4,;17.51,-40.96,;17.16,-39.45,;18.28,-38.41,;18.12,-33.79,;18.04,-32.26,;19.48,-34.51,;20.78,-33.67,;20.71,-32.14,;22.01,-31.31,;21.94,-29.77,;20.57,-29.06,;23.24,-28.94,;22.14,-34.38,;23.44,-33.56,;22.22,-35.92,)|
Structure:
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