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Target
Insulin-degrading enzyme
Ligand
BDBM50427713
Substrate
n/a
Meas. Tech.
ChEMBL_941899 (CHEMBL2329965)
Ki
73±n/a nM
Citation
 Abdul-Hay, SO; Lane, AL; Caulfield, TR; Claussin, C; Bertrand, J; Masson, A; Choudhry, S; Fauq, AH; Maharvi, GM; Leissring, MA Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity. J Med Chem 56:2246-55 (2013) [PubMed]  Article 
Target
Name:
Insulin-degrading enzyme
Synonyms:
Abeta-degrading protease | Human Insulin Degrading Enzyme (hIDE) | IDE | IDE_HUMAN | Insulin degrading enzyme (hIDE) | Insulin protease | Insulin-degrading enzyme | Insulinase | Insulysin | insulin-degrading enzyme isoform 1 precursor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
117968.59
Organism:
Homo sapiens (Human)
Description:
P14735
Residue:
1019
Sequence:
MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
  
Inhibitor
Name:
BDBM50427713
Synonyms:
CHEMBL2324209
Type:
Small organic molecule
Emp. Form.:
C37H45N9O8
Mol. Mass.:
743.8087
SMILES:
NC(N)=NCCC[C@H](NC(=O)[C@H](CC(=O)NO)Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(N)=O |r,wU:7.7,45.48,wD:31.32,11.11,(30.28,-3.68,;31.64,-4.4,;32.94,-3.57,;31.71,-5.93,;30.42,-6.76,;30.48,-8.3,;29.18,-9.12,;29.26,-10.66,;27.96,-11.49,;26.63,-10.72,;26.63,-9.18,;25.29,-11.5,;25.29,-13.04,;23.96,-13.81,;22.62,-13.04,;23.96,-15.35,;22.62,-16.12,;23.99,-10.72,;23.96,-9.18,;22.6,-8.43,;22.57,-6.89,;23.89,-6.1,;23.86,-4.56,;25.17,-3.76,;26.53,-4.5,;26.57,-6.04,;25.25,-6.84,;25.28,-8.38,;30.62,-11.37,;30.69,-12.91,;31.92,-10.54,;33.28,-11.25,;33.36,-12.79,;34.72,-13.5,;36.17,-12.99,;37.1,-14.22,;36.22,-15.48,;36.57,-16.99,;35.44,-18.03,;33.97,-17.59,;33.62,-16.09,;34.75,-15.04,;34.58,-10.43,;34.51,-8.89,;35.95,-11.14,;37.24,-10.3,;37.18,-8.77,;38.48,-7.94,;38.4,-6.4,;37.04,-5.69,;39.7,-5.57,;38.61,-11.02,;39.9,-10.19,;38.68,-12.55,)|
Structure:
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