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Target
Insulin-degrading enzyme
Ligand
BDBM50427700
Substrate
n/a
Meas. Tech.
ChEMBL_941899 (CHEMBL2329965)
Ki
50±n/a nM
Citation
 Abdul-Hay, SO; Lane, AL; Caulfield, TR; Claussin, C; Bertrand, J; Masson, A; Choudhry, S; Fauq, AH; Maharvi, GM; Leissring, MA Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity. J Med Chem 56:2246-55 (2013) [PubMed]  Article 
Target
Name:
Insulin-degrading enzyme
Synonyms:
Abeta-degrading protease | Human Insulin Degrading Enzyme (hIDE) | IDE | IDE_HUMAN | Insulin degrading enzyme (hIDE) | Insulin protease | Insulin-degrading enzyme | Insulinase | Insulysin | insulin-degrading enzyme isoform 1 precursor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
117968.59
Organism:
Homo sapiens (Human)
Description:
P14735
Residue:
1019
Sequence:
MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
  
Inhibitor
Name:
BDBM50427700
Synonyms:
CHEMBL2324204
Type:
Small organic molecule
Emp. Form.:
C35H43N9O7
Mol. Mass.:
701.772
SMILES:
N[C@H](CCC(O)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)NO |r,wU:10.9,35.36,wD:1.0,24.25,(4.44,-15.99,;5.76,-15.2,;5.74,-13.65,;7.07,-12.86,;7.04,-11.33,;5.7,-10.58,;8.36,-10.54,;7.11,-15.95,;7.14,-17.49,;8.43,-15.16,;9.78,-15.91,;9.8,-17.45,;11.15,-18.2,;12.55,-17.55,;13.59,-18.68,;12.85,-20.03,;13.34,-21.48,;12.33,-22.64,;10.81,-22.34,;10.32,-20.89,;11.34,-19.72,;11.11,-15.11,;11.08,-13.58,;12.45,-15.87,;13.77,-15.08,;13.75,-13.54,;15.07,-12.75,;15.05,-11.2,;16.37,-10.41,;16.35,-8.88,;15,-8.12,;17.67,-8.09,;15.12,-15.82,;15.14,-17.36,;16.44,-15.03,;17.78,-15.78,;17.8,-17.32,;19.14,-18.06,;20.45,-17.28,;21.8,-18.02,;21.82,-19.56,;23.16,-20.3,;23.18,-21.83,;21.86,-22.63,;20.52,-21.87,;20.5,-20.34,;19.16,-19.6,;19.1,-14.99,;20.44,-15.74,;19.08,-13.46,;20.39,-12.67,)|
Structure:
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