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Target
Histone-lysine N-methyltransferase SUV39H2
Ligand
BDBM50427772
Substrate
n/a
Meas. Tech.
ChEMBL_941985 (CHEMBL2330205)
IC50
22000±n/a nM
Citation
 Liu, F; Li, F; Ma, A; Dobrovetsky, E; Dong, A; Gao, C; Korboukh, I; Liu, J; Smil, D; Brown, PJ; Frye, SV; Arrowsmith, CH; Schapira, M; Vedadi, M; Jin, J Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors. J Med Chem 56:2110-24 (2013) [PubMed]  Article 
Target
Name:
Histone-lysine N-methyltransferase SUV39H2
Synonyms:
H3-K9-HMTase 2 | Histone H3-K9 methyltransferase 2 | Histone-lysine N-methyltransferase SUV39H2 | Histone-lysine N-methyltransferase SUV39H2 (Suv39H2) | KMT1B | Lysine N-methyltransferase 1B | SUV39H2 | SUV92_HUMAN | Su(var)3-9 homolog 2 | Suppressor of variegation 3-9 homolog 2
Type:
Enzyme
Mol. Mass.:
46692.47
Organism:
Homo sapiens (Human)
Description:
Q9H5I1
Residue:
410
Sequence:
MAAVGAEARGAWCVPCLVSLDTLQELCRKEKLTCKSIGITKRNLNNYEVEYLCDYKVVKDMEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSNDKHNYLSQVKKGKAITPKDNNKTLKPAIAEYIVKKAKQRIALQRWQDELNRRKNHKGMIFVENTVDLEGPPSDFYYINEYKPAPGISLVNEATFGCSCTDCFFQKCCPAEAGVLLAYNKNQQIKIPPGTPIYECNSRCQCGPDCPNRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTRTINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYLN
  
Inhibitor
Name:
BDBM50427772
Synonyms:
CHEMBL2325183
Type:
Small organic molecule
Emp. Form.:
C15H12N4O2S
Mol. Mass.:
312.346
SMILES:
O=C(NCC(=O)c1ccccc1)Nc1ccc2nnsc2c1
Structure:
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