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Target
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Ligand
BDBM50428795
Substrate
n/a
Meas. Tech.
ChEMBL_949339 (CHEMBL2339337)
IC50
2800±n/a nM
Citation
 Scholz, T; Heyl, CL; Bernardi, D; Zimmermann, S; Kattner, L; Klein, CD Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity. Bioorg Med Chem 21:795-804 (2013) [PubMed]  Article 
Target
Name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Synonyms:
EPT | Enoylpyruvate transferase | MURA_ECOLI | MurA (E. coli) | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | UDP-N-acetylglucosamine enolpyruvyl transferase | murA | murZ
Type:
Protein
Mol. Mass.:
44814.62
Organism:
Escherichia coli K-12 (Enterobacteria)
Description:
E. coli MurA
Residue:
419
Sequence:
MDKFRVQGPTKLQGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDVDTSMKLLSQLGAKVERNGSVHIDARDVNVFCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCTIGARPVDLHISGLEQLGATIKLEEGYVKASVDGRLKGAHIVMDKVSVGATVTIMCAATLAEGTTIIENAAREPEIVDTANFLITLGAKISGQGTDRIVIEGVERLGGGVYRVLPDRIETGTFLVAAAISRGKIICRNAQPDTLDAVLAKLRDAGADIEVGEDWISLDMHGKRPKAVNVRTAPHPAFPTDMQAQFTLLNLVAEGTGFITETVFENRFMHVPELSRMGAHAEIESNTVICHGVEKLSGAQVMATDLRASASLVLAGCIAEGTTVVDRIYHIDRGYERIEDKLRALGANIERVKGE
  
Inhibitor
Name:
BDBM50428795
Synonyms:
CHEMBL2335230 | MurA inhibitor (compound 7)
Type:
Small organic molecule
Emp. Form.:
C6H3Br2NO3
Mol. Mass.:
296.901
SMILES:
[O-][N+](=O)C(\Br)=C\c1ccc(Br)o1
Structure:
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