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Target
Histone deacetylase 8
Ligand
BDBM50429533
Substrate
n/a
Meas. Tech.
ChEMBL_944719 (CHEMBL2340965)
Temperature
298.15±n/a K
IC50
20910±n/a nM
Comments
extracted
Citation
 Wagner, FF; Olson, DE; Gale, JP; Kaya, T; Weïwer, M; Aidoud, N; Thomas, M; Davoine, EL; Lemercier, BC; Zhang, YL; Holson, EB Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif. J Med Chem 56:1772-6 (2013) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50429533
Synonyms:
CHEMBL2333338
Type:
Small organic molecule
Emp. Form.:
C15H22N4O3
Mol. Mass.:
306.3602
SMILES:
CN1CCN(CCNC(=O)c2ccc(cc2)C(=O)NO)CC1
Structure:
Search PDB for entries with ligand similarity: