Target
Alpha-ketoglutarate-dependent dioxygenase FTO
Ligand
BDBM50277935
Substrate
n/a
Meas. Tech.
ChEMBL_947323 (CHEMBL2344107)
IC50
110000±n/a nM
Citation
 Aik, WDemetriades, MHamdan, MKBagg, EAYeoh, KKLejeune, CZhang, ZMcDonough, MASchofield, CJ Structural basis for inhibition of the fat mass and obesity associated protein (FTO). J Med Chem 56:3680-8 (2013) [PubMed]  Article 
Target
Name:
Alpha-ketoglutarate-dependent dioxygenase FTO
Synonyms:
FTO | FTO_HUMAN | Fat mass and obesity-associated protein | KIAA1752
Type:
PROTEIN
Mol. Mass.:
58263.75
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1515854
Residue:
505
Sequence:
MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVGMGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDDLNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCDDVDNDDVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHEVKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDASMPLPFDLTDIVSELRGQLLEAKP
  
Inhibitor
Name:
BDBM50277935
Synonyms:
(S)-2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)propanoic acid | CHEMBL485022
Type:
Small organic molecule
Emp. Form.:
C13H11ClN2O4
Mol. Mass.:
294.69
SMILES:
C[C@H](NC(=O)c1nc(Cl)c2ccccc2c1O)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: