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Target
D-amino-acid oxidase
Ligand
BDBM50431066
Substrate
n/a
Meas. Tech.
ChEMBL_947859 (CHEMBL2343135)
IC50
2.4±n/a nM
Citation
 Hondo, T; Warizaya, M; Niimi, T; Namatame, I; Yamaguchi, T; Nakanishi, K; Hamajima, T; Harada, K; Sakashita, H; Matsumoto, Y; Orita, M; Takeuchi, M 4-Hydroxypyridazin-3(2H)-one derivatives as novel D-amino acid oxidase inhibitors. J Med Chem 56:3582-92 (2013) [PubMed]  Article 
Target
Name:
D-amino-acid oxidase
Synonyms:
D-amino-acid oxidase (DAAO) | DAAO | DAMOX | DAO | OXDA_HUMAN
Type:
Homodimer
Mol. Mass.:
39476.06
Organism:
Homo sapiens (Human)
Description:
P14920
Residue:
347
Sequence:
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL
  
Inhibitor
Name:
BDBM50431066
Synonyms:
CHEMBL2338798 | US10202399, Example 17 | US10463663, Example 11 | US11129828, Example 11 | US9212147, 17 | US9290456, 11 | US9931340, Example 11
Type:
Small organic molecule
Emp. Form.:
C13H11F3N2O2
Mol. Mass.:
284.2338
SMILES:
Oc1cc(CCc2cccc(c2)C(F)(F)F)n[nH]c1=O
Structure:
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