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Target
Aminopeptidase N
Ligand
BDBM50353016
Substrate
n/a
Meas. Tech.
ChEMBL_951230 (CHEMBL2353231)
Ki
10.0±n/a nM
Citation
 Schmitt, C; Voegelin, M; Marin, A; Schmitt, M; Schegg, F; Hénon, P; Guenot, D; Tarnus, C Selective aminopeptidase-N (CD13) inhibitors with relevance to cancer chemotherapy. Bioorg Med Chem 21:2135-44 (2013) [PubMed]  Article 
Target
Name:
Aminopeptidase N
Synonyms:
AMPN_MOUSE | AP-M | AP-N | Alanyl aminopeptidase | Anpep | CD_antigen=CD13 | Lap-1 | Lap1 | Membrane protein p161 | Microsomal aminopeptidase | mAPN
Type:
PROTEIN
Mol. Mass.:
109642.29
Organism:
Mus musculus
Description:
ChEMBL_879875
Residue:
966
Sequence:
MAKGFYISKTLGILGILLGVAAVCTIIALSVVYAQEKNRNAENSATAPTLPGSTSATTATTTPAVDESKPWNQYRLPKTLIPDSYRVILRPYLTPNNQGLYIFQGNSTVRFTCNQTTDVIIIHSKKLNYTLKGNHRVVLRTLDGTPAPNIDKTELVERTEYLVVHLQGSLVEGRQYEMDSQFQGELADDLAGFYRSEYMEGDVKKVVATTQMQAADARKSFPCFDEPAMKAMFNITLIYPNNLIALSNMLPKESKPYPEDPSCTMTEFHSTPKMSTYLLAYIVSEFKNISSVSANGVQIGIWARPSAIDEGQGDYALNVTGPILNFFAQHYNTSYPLPKSDQIALPDFNAGAMENWGLVTYRESSLVFDSQSSSISNKERVVTVIAHELAHQWFGNLVTVAWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSSPADEIKTPDQIMELFDSITYSKGASVIRMLSSFLTEDLFKKGLSSYLHTYQYSNTVYLDLWEHLQKAVNQQTAVQPPATVRTIMDRWILQMGFPVITVNTNTGEISQKHFLLDSKSNVTRPSEFNYIWIAPIPFLKSGQEDHYWLDVEKNQSAKFQTSSNEWILLNINVTGYYLVNYDENNWKKLQNQLQTDLSVIPVINRAQIIHDSFNLASAKMIPITLALDNTLFLVKEAEYMPWQAALSSLNYFTLMFDRSEVYGPMKRYLKKQVTPLFFYFQNRTNNWVNRPPTLMEQYNEINAISTACSSGLKECRDLVVELYSQWMKNPNNNTIHPNLRSTVYCNAIAFGGEEEWNFAWEQFRNATLVNEADKLRSALACSKDVWILNRYLSYTLNPDYIRKQDTTSTIISIASNVAGHPLVWDFVRSNWKKLFENYGGGSFSFANLIQGVTRRFSSEFELQQLEQFKADNSATGFGTGTRALEQALEKTRANIDWVKENKDAVFKWFTENSS
  
Inhibitor
Name:
BDBM50353016
Synonyms:
CHEMBL1821978
Type:
Small organic molecule
Emp. Form.:
C17H17NO
Mol. Mass.:
251.323
SMILES:
NC1CCc2cccc(c2CC1=O)-c1ccccc1
Structure:
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