Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50058020
Substrate
n/a
Meas. Tech.
ChEMBL_949952 (CHEMBL2352307)
Ki
0.670000±n/a nM
Citation
 Li, Y; Wang, X; Zhang, J; Deuther-Conrad, W; Xie, F; Zhang, X; Liu, J; Qiao, J; Cui, M; Steinbach, J; Brust, P; Liu, B; Jia, H Synthesis and evaluation of novel (18)F-labeled spirocyclic piperidine derivatives ass1 receptor ligands for positron emission tomography imaging. J Med Chem 56:3478-91 (2013) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50058020
Synonyms:
4-[1-((E)-3-Iodo-allyl)-piperidin-4-ylmethoxy]-benzonitrile | CHEMBL2347004 | CHEMBL274585
Type:
Small organic molecule
Emp. Form.:
C16H19IN2O
Mol. Mass.:
382.2393
SMILES:
I\C=C\CN1CCC(COc2ccc(cc2)C#N)CC1
Structure:
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