Reaction Details Report a problem with these data
Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50432935
Substrate
n/a
Meas. Tech.
ChEMBL_957421 (CHEMBL2378091)
EC50
72±n/a nM
Citation
 Nair, SK; Matthews, JJ; Cripps, SJ; Cheng, H; Hoffman, JE; Smith, C; Kupchinsky, S; Siu, M; Taylor, WD; Wang, Y; Johnson, TO; Dress, KR; Edwards, MP; Zhou, S; Hosea, NA; Lapaglia, A; Kang, P; Castro, A; Ermolieff, J; Fanjul, A; Vogel, JE; Rejto, P; Dalvie, D N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11ß-hydroxysteroid dehydrogenase type 1: strategies to eliminate reactive metabolites. Bioorg Med Chem Lett 23:2344-8 (2013) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50432935
Synonyms:
CHEMBL2377210
Type:
Small organic molecule
Emp. Form.:
C21H14N4O2S
Mol. Mass.:
386.426
SMILES:
O=S(=O)(Nc1ccc2ncccc2n1)c1ccc(cc1)-c1ccc(cc1)C#N
Structure:
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