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Target
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Ligand
BDBM50433269
Substrate
n/a
Meas. Tech.
ChEMBL_957769 (CHEMBL2378802)
IC50
79±n/a nM
Citation
 Barlind, JG; Buckett, LK; Crosby, SG; Davidsson, Ö; Emtenäs, H; Ertan, A; Jurva, U; Lemurell, M; Gutierrez, PM; Nilsson, K; O'Mahony, G; Petersson, AU; Redzic, A; Wågberg, F; Yuan, ZQ Identification and design of a novel series of MGAT2 inhibitors. Bioorg Med Chem Lett 23:2721-6 (2013) [PubMed]  Article 
Target
Name:
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Synonyms:
Beta-1,2-N-acetylglucosaminyltransferase II | GNT-II | GlcNAc-T II | MGAT2_MOUSE | Mannoside acetylglucosaminyltransferase 2 | Mgat2 | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II
Type:
PROTEIN
Mol. Mass.:
51045.37
Organism:
Mus musculus
Description:
ChEMBL_107583
Residue:
442
Sequence:
MRFRIYKRKVLILTLVVAACGFVLWSSNGRQRKSDALGPPLLDAEPVRGAGHLAVSVGIRRVSNESAAPLVPAVPRPEVDNLTLRYRSLVYQLNFDQMLRNVGNDGTWSPGELVLVVQVHNRPEYLRLLIDSLRKAQGIQEVLVIFSHDFWSAEINSLISRVDFCPVLQVFFPFSIQLYPNEFPGSDPRDCPRDLKKNAALKLGCINAEYPDSFGHYREAKFSQTKHHWWWKLHFVWERVKVLQDYTGLILFLEEDHYLAPDFYHVFKKMWKLKQQECPGCDVLSLGTYTTIRSFYGIADKVDVKTWKSTEHNMGLALTRDAYQKLIECTDTFCTYDDYNWDWTLQYLTLACLPKIWKVLVPQAPRIFHAGDCGMHHKKTCRPSTQSAQIESLLNSNKQYLFPETLVIGEKFPMAAISPPRKNGGWGDIRDHELCKSYRRLQ
  
Inhibitor
Name:
BDBM50433269
Synonyms:
CHEMBL2376303
Type:
Small organic molecule
Emp. Form.:
C18H17F2N3O4S
Mol. Mass.:
409.407
SMILES:
CC[C@]1(C)NC(=O)c2cc(ccc2NC1=O)S(=O)(=O)Nc1ccc(F)cc1F |r|
Structure:
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