Target
Methionine aminopeptidase 1
Ligand
BDBM50433389
Substrate
n/a
Meas. Tech.
ChEMBL_957175 (CHEMBL2378713)
EC50
180±n/a nM
Citation
 Zhang, FBhat, SGabelli, SBChen, XMiller, MSNacev, BACheng, YLMeyers, DJTenney, KShim, JSCrews, PAmzel, LMMa, DLiu, JO Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells. J Med Chem 56:3996-4016 (2013) [PubMed]  Article 
Target
Name:
Methionine aminopeptidase 1
Synonyms:
Aminopeptidase | KIAA0094 | MAP 1 | MAP11_HUMAN | METAP1 | MetAP 1 | Methionine Aminopeptidase Type 1 (MetAP1) | Peptidase M 1
Type:
Enzyme
Mol. Mass.:
43220.79
Organism:
Homo sapiens (Human)
Description:
MetAP1 with an N-terminal six histidine tag was expressed in baculovirus infected sf9 cells.
Residue:
386
Sequence:
MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKAKREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMSQF
  
Inhibitor
Name:
BDBM50433389
Synonyms:
CHEMBL2375618
Type:
Small organic molecule
Emp. Form.:
C28H28N4O3
Mol. Mass.:
468.5469
SMILES:
CCOC(=O)COc1ccc(cc1)N1CCN(CC1)c1cc(nc2ccccc12)-c1ccccn1
Structure:
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