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Target
Methionine aminopeptidase 1
Ligand
BDBM17847
Substrate
n/a
Meas. Tech.
ChEMBL_957175 (CHEMBL2378713)
EC50
360±n/a nM
Citation
 Zhang, F; Bhat, S; Gabelli, SB; Chen, X; Miller, MS; Nacev, BA; Cheng, YL; Meyers, DJ; Tenney, K; Shim, JS; Crews, P; Amzel, LM; Ma, D; Liu, JO Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells. J Med Chem 56:3996-4016 (2013) [PubMed]  Article 
Target
Name:
Methionine aminopeptidase 1
Synonyms:
Aminopeptidase | KIAA0094 | MAP 1 | MAP11_HUMAN | METAP1 | MetAP 1 | Methionine Aminopeptidase Type 1 (MetAP1) | Peptidase M 1
Type:
Enzyme
Mol. Mass.:
43220.79
Organism:
Homo sapiens (Human)
Description:
MetAP1 with an N-terminal six histidine tag was expressed in baculovirus infected sf9 cells.
Residue:
386
Sequence:
MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKAKREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMSQF
  
Inhibitor
Name:
BDBM17847
Synonyms:
CHEMBL327579 | pyridine-2-carboxylic acid inhibitor, 1 | tert-butyl N-[2-(1,3-thiazol-2-ylcarbamoyl)pyridin-3-yl]carbamate
Type:
Small organic molecule
Emp. Form.:
C14H16N4O3S
Mol. Mass.:
320.367
SMILES:
CC(C)(C)OC(=O)Nc1cccnc1C(=O)Nc1nccs1
Structure:
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