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Target
Muscarinic acetylcholine receptor M5
Ligand
BDBM50433574
Substrate
n/a
Meas. Tech.
ChEMBL_960029 (CHEMBL2384199)
EC50
0.224000±n/a nM
Citation
 Gentry, PR; Bridges, TM; Lamsal, A; Vinson, PN; Smith, E; Chase, P; Hodder, PS; Engers, JL; Niswender, CM; Daniels, JS; Jeffrey Conn, P; Wood, MR; Lindsley, CW Discovery of ML326: The first sub-micromolar, selective M5 PAM. Bioorg Med Chem Lett 23:2996-3000 (2013) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M5
Synonyms:
ACM5_RAT | Cholinergic, muscarinic M5 | Chrm-5 | Chrm5 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M5
Type:
Enzyme Catalytic Domain
Mol. Mass.:
60161.80
Organism:
RAT
Description:
Cholinergic, muscarinic M5 CHRM5 RAT::P08911
Residue:
531
Sequence:
MEGESYNESTVNGTPVNHQALERHGLWEVITIAVVTAVVSLMTIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWVLGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLVSFILWAPAILCWQYLVGKRTVPPDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVAEAKKREPAQRTLLRSFFSCPRPSLAQRERNQASWSSSRRSTSTTGKTTQATDLSADWEKAEQVTTCSSYPSSEDEAKPTTDPVFQMVYKSEAKESPGKESNTQETKETVVNTRTENSDYDTPKYFLSPAAAHRLKSQKCVAYKFRLVVKADGTQETNNGCRKVKIMPCSFPVSKDPSTKGPDPNLSHQMTKRKRMVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTINPICYALCNRTFRKTFKLLLLCRWKKKKVEEKLYWQGNSKLP
  
Inhibitor
Name:
BDBM50433574
Synonyms:
CHEMBL2381694
Type:
Small organic molecule
Emp. Form.:
C17H12F3NO4
Mol. Mass.:
351.2767
SMILES:
FC(F)(F)Oc1ccc2N(CCOc3ccccc3)C(=O)C(=O)c2c1
Structure:
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