Target
E3 ubiquitin-protein ligase XIAP
Ligand
BDBM44311
Substrate
n/a
Meas. Tech.
ChEMBL_971509 (CHEMBL2406571)
Ki
1830±n/a nM
Citation
 Ardecky, RJWelsh, KFinlay, DLee, PSGonzález-López, MGanji, SRRavanan, PMace, PDRiedl, SJVuori, KReed, JCCosford, ND Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP. Bioorg Med Chem Lett 23:4253-7 (2013) [PubMed]  Article 
Target
Name:
E3 ubiquitin-protein ligase XIAP
Synonyms:
API3 | BIRC4 | E3 ubiquitin-protein ligase XIAP | IAP3 | Inhibitor of apoptosis protein 3 | Inhibitor of apoptosis protein 3 (XIAP) | X-linked inhibitor of apoptosis | X-linked inhibitor of apoptosis protein (XIAP) | XIAP | XIAP_HUMAN
Type:
Protein
Mol. Mass.:
56685.27
Organism:
Homo sapiens (Human)
Description:
P98170
Residue:
497
Sequence:
MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS
  
Inhibitor
Name:
BDBM44311
Synonyms:
(2S)-2-[[(2S)-2-amino-1-oxopropyl]amino]-3-methyl-N-[(2S)-1-oxo-1-(phenylhydrazo)propan-2-yl]butanamide;formic acid | (2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-methyl-N-[(2S)-1-oxo-1-(2-phenylhydrazinyl)propan-2-yl]butanamide;formic acid | (2S)-2-[[(2S)-2-aminopropanoyl]amino]-N-[(1S)-2-keto-1-methyl-2-(N'-phenylhydrazino)ethyl]-3-methyl-butyramide;formic acid | (2S)-2-[[(2S)-2-azanylpropanoyl]amino]-3-methyl-N-[(2S)-1-oxidanylidene-1-(2-phenylhydrazinyl)propan-2-yl]butanamide;methanoic acid | CHEMBL1617819 | MLS-0412113.0001 | cid_44182205
Type:
Small organic molecule
Emp. Form.:
C17H27N5O3
Mol. Mass.:
349.428
SMILES:
CC(C)[C@H](NC(=O)[C@H](C)N)C(=O)N[C@@H](C)C(=O)NNc1ccccc1
Structure:
Search PDB for entries with ligand similarity: