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Target
Tubulin polyglutamylase TTLL7
Ligand
BDBM50437187
Substrate
n/a
Meas. Tech.
ChEMBL_970237 (CHEMBL2406640)
IC50
150000±n/a nM
Citation
 Liu, Y; Garnham, CP; Roll-Mecak, A; Tanner, ME Phosphinic acid-based inhibitors of tubulin polyglutamylases. Bioorg Med Chem Lett 23:4408-12 (2013) [PubMed]  Article 
Target
Name:
Tubulin polyglutamylase TTLL7
Synonyms:
TTLL7_MOUSE | Ttll7 | Tubulin--tyrosine ligase-like protein 7
Type:
PROTEIN
Mol. Mass.:
105539.60
Organism:
Mus musculus
Description:
ChEMBL_107621
Residue:
912
Sequence:
MPSLPQDGVIQGSSPVDLGTELPYQCTMKRKVRKKKKKGIITANVAGTKFEIVRLVIDEMGFMKTPDEDETSNLIWCDAAVQQEKITDLQNYQRINHFPGMGEICRKDFLARNMTKMIKSRPMDYTFVPRTWIFPSEYTQFQNYVKELKKKRKQKTFIVKPANGAMGHGISLIRNGDKVPSQDHLIVQEYIEKPFLMEGYKFDLRIYILVTSCDPLKIFLYHDGLVRMGTEKYIPPNESNLTQLYMHLTNYSVNKHNERFERNETEDKGSKRSIKWFTEFLQANQHDVTKFWSDISELVVKTLIVAEPHVLHAYRMCRPGQPPGSESVCFEVLGFDILLDRKLKPWLLEINRAPSFGTDQKIDYDVKRGVLLNALKLLNIRTSDKRKNLAKQKAEAQRRLYGQNPVRRLSPGSSDWEQQRHQLERRKEELKERLLQVRKQVSQEEHENRHMGNYRRIYPPEDKALLEKYEGLLAVAFQTFLSGRAASFQREMNNPLKKMREEDLLDLLEQCEIDDEKLMGKTGRVRGPKPLCCMPECAEVTKKQKYYGSSDSSYDSSSSSSNSELDENEKELCQKRLDQVPYSLKHTSHCKIIQQPSGSHNLIYSESPVYLTTLVFLSEFPDSMRRSVSCPRSISAHLPSRGDVRPFSSQQVIPLARPTSASRSHSLNRASSYARHLPHGSDTGSTNTLNESLRQLKTKEQEDDLTSQTLFVLKDMRIRFPGKSDAESELLIEDIMDNWKHYKTKVASYWLIKLDSVKQRKVLDIVKSSIRTVLPRIWRVPDAEELSLYRIFNRVFNRLLWSHGQGLWSCFCDSGSSWESIFSKSPEVVTPLQLQCCQRLVELCKQCLLVVYKYTTETRGPISGIGPDWGNSRYLLPGSTQFLMRSPLYNMKYNSPGMTRSNVLFTSRYGRL
  
Inhibitor
Name:
BDBM50437187
Synonyms:
CHEMBL2401837
Type:
Small organic molecule
Emp. Form.:
C12H20NO9P
Mol. Mass.:
353.2623
SMILES:
CC(=O)NC(CCC(O)=O)P(O)(=O)CC(CCC(O)=O)C(O)=O
Structure:
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