Reaction Details Report a problem with these data
Target
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal
Ligand
BDBM50438271
Substrate
n/a
Meas. Tech.
ChEMBL_973313 (CHEMBL2412700)
Ki
57610±n/a nM
Citation
 Soares, FA; Sesti-Costa, R; da Silva, JS; de Souza, MC; Ferreira, VF; Santos, Fda C; Monteiro, PA; Leitão, A; Montanari, CA Molecular design, synthesis and biological evaluation of 1,4-dihydro-4-oxoquinoline ribonucleosides as TcGAPDH inhibitors with trypanocidal activity. Bioorg Med Chem Lett 23:4597-601 (2013) [PubMed]  Article 
Target
Name:
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal
Synonyms:
G3PG_TRYCR
Type:
PROTEIN
Mol. Mass.:
39070.68
Organism:
Trypanosoma cruzi
Description:
ChEMBL_973242
Residue:
359
Sequence:
MPIKVGINGFGRIGRMVFQALCEDGLLGTEIDVVAVVDMNTDAEYFAYQMRYDTVHGKFKYEVTTTKSSPSVAKDDTLVVNGHRILCVKAQRNPADLPWGKLGVEYVIESTGLFTAKAAAEGHLRGGARKVVISAPASGGAKTLVMGVNHHEYNPSEHHVVSNASCTTNCLAPIVHVLVKEGFGVQTGLMTTIHSYTATQKTVDGVSVKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTQGKLTGMSFRVPTPDVSVVDLTFTAARDTSIQEIDAALKRASKTYMKGILGYTDEELVSADFINDNRSSIYDSKATLQNNLPKERRFFKIVSWYDNEWGYSHRVVDLVRHMASKDRSARL
  
Inhibitor
Name:
BDBM50438271
Synonyms:
CHEMBL2408385
Type:
Small organic molecule
Emp. Form.:
C16H17NO7
Mol. Mass.:
335.3087
SMILES:
Cc1ccc2n(cc(C(O)=O)c(=O)c2c1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O |r|
Structure:
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