Target
N-acylethanolamine-hydrolyzing acid amidase
Ligand
BDBM50389023
Substrate
n/a
Meas. Tech.
ChEMBL_978419 (CHEMBL2421061)
IC50
7.0±n/a nM
Citation
 Ponzano, SBertozzi, FMengatto, LDionisi, MArmirotti, ARomeo, EBerteotti, AFiorelli, CTarozzo, GReggiani, ADuranti, ATarzia, GMor, MCavalli, APiomelli, DBandiera, T Synthesis and structure-activity relationship (SAR) of 2-methyl-4-oxo-3-oxetanylcarbamic acid esters, a class of potent N-acylethanolamine acid amidase (NAAA) inhibitors. J Med Chem 56:6917-34 (2013) [PubMed]  Article 
Target
Name:
N-acylethanolamine-hydrolyzing acid amidase
Synonyms:
ASAH-like protein | ASAHL | Acid ceramidase-like protein | N-acylethanolamine-hydrolyzing acid amidase | N-acylsphingosine amidohydrolase-like | N-acylsphingosine-amidohydrolase | NAAA | NAAA_HUMAN | PLT
Type:
Enzyme
Mol. Mass.:
40073.12
Organism:
Homo sapiens (Human)
Description:
Q02083
Residue:
359
Sequence:
MRTADREARPGLPSLLLLLLAGAGLSAASPPAAPRFNVSLDSVPELRWLPVLRHYDLDLVRAAMAQVIGDRVPKWVHVLIGKVVLELERFLPQPFTGEIRGMCDFMNLSLADCLLVNLAYESSVFCTSIVAQDSRGHIYHGRNLDYPFGNVLRKLTVDVQFLKNGQIAFTGTTFIGYVGLWTGQSPHKFTVSGDERDKGWWWENAIAALFRRHIPVSWLIRATLSESENFEAAVGKLAKTPLIADVYYIVGGTSPREGVVITRNRDGPADIWPLDPLNGAWFRVETNYDHWKPAPKEDDRRTSAIKALNATGQANLSLEALFQILSVVPVYNNFTIYTTVMSAGSPDKYMTRIRNPSRK
  
Inhibitor
Name:
BDBM50389023
Synonyms:
CHEMBL2064166 | US9353075, 6
Type:
Small organic molecule
Emp. Form.:
C16H21NO4
Mol. Mass.:
291.3422
SMILES:
C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCCc1ccccc1 |r|
Structure:
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