Reaction Details Report a problem with these data
Target
Virulence factor transcriptional regulator MvfR
Ligand
BDBM50440130
Substrate
n/a
Meas. Tech.
ChEMBL_983772 (CHEMBL2428111)
Kd
4500±n/a nM
Citation
 Zender, M; Klein, T; Henn, C; Kirsch, B; Maurer, CK; Kail, D; Ritter, C; Dolezal, O; Steinbach, A; Hartmann, RW Discovery and biophysical characterization of 2-amino-oxadiazoles as novel antagonists of PqsR, an important regulator of Pseudomonas aeruginosa virulence. J Med Chem 56:6761-74 (2013) [PubMed]  Article 
Target
Name:
Virulence factor transcriptional regulator MvfR
Synonyms:
Transcriptional regulator MvfR
Type:
PROTEIN
Mol. Mass.:
37217.11
Organism:
Pseudomonas aeruginosa PA14
Description:
ChEMBL_107649
Residue:
332
Sequence:
MPIHNLNHVNMFLQVIASGSISSAARILRKSHTAVSSAVSNLEIDLCVELVRRDGYKVEPTEQALRLIPYMRSLLNYQQLIGDIAFNLNKGPRNLRVLLDTAIPPSFCDTVSSVLLDDFNMVSLIRTSPADSLATIKQDNAEIDIAITIDEELKISRFNQCVLGYTKAFVVAHPQHPLCNASLHSIASLANYRQISLGSRSGQHSNLLRPVSDKVLFVENFDDMLRLVEAGVGWGIAPHYFVEERLRNGTLAVLSELYEPGGIDTKVYCYYNTALESERSFLRFLESARQRLRELGRQRFDDAPAWQPSIVETAQRRSGPKALAYRQRAAPE
  
Inhibitor
Name:
BDBM50440130
Synonyms:
CHEMBL1383520 | US11634391, Compound 168
Type:
Small organic molecule
Emp. Form.:
C8H6ClN3S
Mol. Mass.:
211.671
SMILES:
Nc1nnc(s1)-c1ccc(Cl)cc1
Structure:
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