Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50005095
Substrate
n/a
Meas. Tech.
ChEMBL_982012 (CHEMBL2428367)
Ki
151±n/a nM
Citation
 McClure, KFJackson, MCameron, KOKung, DWPerry, DAOrr, STZhang, YKohrt, JTu, MGao, HFernando, DJones, RErasga, NWang, GPolivkova, JJiao, WSwartz, RUeno, HBhattacharya, SKStock, IAVarma, SBagdasarian, VPerez, SKelly-Sullivan, DWang, RKong, JCornelius, PMichael, LLee, EJanssen, ASteyn, SJLapham, KGoosen, T Identification of potent, selective, CNS-targeted inverse agonists of the ghrelin receptor. Bioorg Med Chem Lett 23:5410-4 (2013) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2
Type:
GPCR
Mol. Mass.:
51730.61
Organism:
Homo sapiens (Human)
Description:
P08172
Residue:
466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50005095
Synonyms:
CHEMBL2426672
Type:
Small organic molecule
Emp. Form.:
C29H35N5O2
Mol. Mass.:
485.6205
SMILES:
COc1ccc(CC(=O)N2CCC3(CN(C3)C(C(C)C)c3ccc(cc3)-c3ncccn3)CC2)nc1
Structure:
Search PDB for entries with ligand similarity: