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TargetSigma non-opioid intracellular receptor 1
LigandBDBM50441458
Substrate/Competitorn/a
Meas. Tech.ChEMBL_988325
Ki 6146±n/a nM
Citation Dukat, MAlix, KWorsham, JKhatri, SSchulte, MK 2-Amino-6-chloro-3,4-dihydroquinazoline: A novel 5-HT3 receptor antagonist with antidepressant character. Bioorg Med Chem Lett23:5945-8 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sigma non-opioid intracellular receptor 1
Name:Sigma-1 receptor
Synonyms:OPRS1 | SIGMAR1 | Sigma 1-type opioid receptor | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:Protein
Mol. Mass.:25307.17
Organism:Cavia porcellus (Guinea pig)
Description:Q60492
Residue:223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSK
LIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
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  Blast E-value cutoff:
BDBM50441458
NameBDBM50441458
Synonyms:CHEMBL2436555
TypeSmall organic molecule
Emp. Form.C8H8ClN3
Mol. Mass.181.622
SMILESNC1=NCc2cc(Cl)ccc2N1 |t:1|
Structure
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n/a