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Target
Uridine phosphorylase 1
Ligand
BDBM50026387
Substrate
n/a
Meas. Tech.
ChEMBL_1275625 (CHEMBL3090756)
Kd
1200±n/a nM
Citation
 Renck, D; Machado, P; Souto, AA; Rosado, LA; Erig, T; Campos, MM; Farias, CB; Roesler, R; Timmers, LF; de Souza, ON; Santos, DS; Basso, LA Design of novel potent inhibitors of human uridine phosphorylase-1: synthesis, inhibition studies, thermodynamics, and in vitro influence on 5-fluorouracil cytotoxicity. J Med Chem 56:8892-902 (2013) [PubMed]  Article 
Target
Name:
Uridine phosphorylase 1
Synonyms:
UP | UPP1 | UPP1_HUMAN | UPase 1 | UrdPase 1 | Uridine phosphorylase (UPase)
Type:
Enzyme
Mol. Mass.:
33939.54
Organism:
Homo sapiens (Human)
Description:
Q16831
Residue:
310
Sequence:
MAATGANAEKAESHNDCPVRLLNPNIAKMKEDILYHFNLTTSRHNFPALFGDVKFVCVGGSPSRMKAFIRCVGAELGLDCPGRDYPNICAGTDRYAMYKVGPVLSVSHGMGIPSISIMLHELIKLLYYARCSNVTIIRIGTSGGIGLEPGTVVITEQAVDTCFKAEFEQIVLGKRVIRKTDLNKKLVQELLLCSAELSEFTTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLEAAYAAGVRNIEMESSVFAAMCSACGLQAAVVCVTLLNRLEGDQISSPRNVLSEYQQRPQRLVSYFIKKKLSKA
  
Inhibitor
Name:
BDBM50026387
Synonyms:
1-((2-HYDROXYETHOXY)METHYL)-5-BENZYLPYRIMIDINE-2,4(1H,3H)-DIONE | 5-Benzyl-1-(2-hydroxy-ethoxymethyl)-1H-pyrimidine-2,4-dione | CHEMBL17432
Type:
Small organic molecule
Emp. Form.:
C14H16N2O4
Mol. Mass.:
276.2878
SMILES:
OCCOCn1cc(Cc2ccccc2)c(=O)[nH]c1=O
Structure:
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