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TargetMacrophage colony-stimulating factor 1 receptor (c-Fms)
LigandBDBM50443132
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1276354
IC50 1.8±n/a nM
Citation Illig, CRManthey, CLMeegalla, SKWall, MJChen, JWilson, KJDesJarlais, RLBallentine, SKSchubert, CCrysler, CSChen, YMolloy, CJChaikin, MADonatelli, RRYurkow, EZhou, ZPlayer, MRTomczuk, BE Enhancement of kinase selectivity in a potent class of arylamide FMS inhibitors. Bioorg Med Chem Lett23:6363-9 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Macrophage colony-stimulating factor 1 receptor (c-Fms)
Name:Macrophage colony-stimulating factor 1 receptor (c-Fms)
Synonyms:Macrophage colony-stimulating factor 1 receptor | Proto-oncogene c-Fms
Type:Protein
Mol. Mass.:109173.45
Organism:Mus musculus (Mouse)
Description:P09581
Residue:977
Sequence:
MELGPPLVLLLATVWHGQGAPVIEPSGPELVVEPGETVTLRCVSNGSVEWDGPISPYWTL
DPESPGSTLTTRNATFKNTGTYRCTELEDPMAGSTTIHLYVKDPAHSWNLLAQEVTVVEG
QEAVLPCLITDPALKDSVSLMREGGRQVLRKTVYFFSPWRGFIIRKAKVLDSNTYVCKTM
VNGRESTSTGIWLKVNRVHPEPPQIKLEPSKLVRIRGEAAQIVCSATNAEVGFNVILKRG
DTKLEIPLNSDFQDNYYKKVRALSLNAVDFQDAGIYSCVASNDVGTRTATMNFQVVESAY
LNLTSEQSLLQEVSVGDSLILTVHADAYPSIQHYNWTYLGPFFEDQRKLEFITQRAIYRY
TFKLFLNRVKASEAGQYFLMAQNKAGWNNLTFELTLRYPPEVSVTWMPVNGSDVLFCDVS
GYPQPSVTWMECRGHTDRCDEAQALQVWNDTHPEVLSQKPFDKVIIQSQLPIGTLKHNMT
YFCKTHNSVGNSSQYFRAVSLGQSKQLPDESLFTPVVVACMSVMSLLVLLLLLLLYKYKQ
KPKYQVRWKIIERYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAF
GLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVI
TEYCCYGDLLNFLRRKAEAMLGPSLSPGQDSEGDSSYKNIHLEKKYVRRDSGFSSQGVDT
YVEMRPVSTSSSDSFFKQDLDKEASRPLELWDLLHFSSQVAQGMAFLASKNCIHRDVAAR
NVLLTSGHVAKIGDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTVQSDVWSYG
ILLWEIFSLGLNPYPGILVNNKFYKLVKDGYQMAQPVFAPKNIYSIMQSCWDLEPTRRPT
FQQICFLLQEQARLERRDQDYANLPSSGGSSGSDSGGGSSGGSSSEPEEESSSEHLACCE
PGDIAQPLLQPNNYQFC
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  Blast E-value cutoff:
BDBM50443132
NameBDBM50443132
Synonyms:CHEMBL3086175 | US9221797, 42
TypeSmall organic molecule
Emp. Form.C23H27N5O2
Mol. Mass.405.4928
SMILESO=C(Nc1ccc(CCN2CCOCC2)cc1C1=CCCCC1)c1ncc([nH]1)C#N |t:19|
Structure
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n/a