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Target
Kallikrein-7
Ligand
BDBM50444598
Substrate
n/a
Meas. Tech.
ChEMBL_1282454 (CHEMBL3100881)
IC50
83000±n/a nM
Citation
 Tan, X; Bertonati, C; Qin, L; Furio, L; El Amri, C; Hovnanian, A; Reboud-Ravaux, M; Villoutreix, BO Identification by in silico and in vitro screenings of small organic molecules acting as reversible inhibitors of kallikreins. Eur J Med Chem 70:661-8 (2013) [PubMed]  Article 
Target
Name:
Kallikrein-7
Synonyms:
KLK7 | KLK7_HUMAN | Kallikrein 7 | Kallikrein-7 | PRSS6 | SCCE | Serine protease 6 | Stratum corneum chymotryptic enzyme | hK7 | hSCCE | kallikrein-7 isoform 1 preproprotein
Type:
PROTEIN
Mol. Mass.:
27535.05
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469257
Residue:
253
Sequence:
MARSLLLPLQILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTKWINDTMKKHR
  
Inhibitor
Name:
BDBM50444598
Synonyms:
CHEMBL3099878
Type:
Small organic molecule
Emp. Form.:
C23H22N4O4
Mol. Mass.:
418.4452
SMILES:
COc1cc(\C=C(\C#N)c2nc3ccccc3[nH]2)ccc1OCC(=O)N1CCOCC1
Structure:
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