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Target
Low molecular weight phosphotyrosine protein phosphatase
Ligand
BDBM50444692
Substrate
n/a
Meas. Tech.
ChEMBL_1281646 (CHEMBL3102583)
IC50
17200±n/a nM
Citation
 Ottanà, R; Maccari, R; Mortier, J; Caselli, A; Amuso, S; Camici, G; Rotondo, A; Wolber, G; Paoli, P Synthesis, biological activity and structure-activity relationships of new benzoic acid-based protein tyrosine phosphatase inhibitors endowed with insulinomimetic effects in mouse C2C12 skeletal muscle cells. Eur J Med Chem 71:112-27 (2014) [PubMed]  Article 
Target
Name:
Low molecular weight phosphotyrosine protein phosphatase
Synonyms:
3.1.3.2 | 3.1.3.48 | ACP1 | Adipocyte acid phosphatase | LMW-PTP | LMW-PTPase | LMWPTP | Low molecular weight cytosolic acid phosphatase | PPAC_HUMAN | Red cell acid phosphatase 1 | low molecular weight phosphotyrosine protein phosphatase isoform c
Type:
n/a
Mol. Mass.:
18042.81
Organism:
Homo sapiens (Human)
Description:
P24666
Residue:
158
Sequence:
MAEQATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYEIGNPPDYRGQSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKSNQVKTCKAKIELLGSYDPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLEKAH
  
Inhibitor
Name:
BDBM50444692
Synonyms:
CHEMBL3098853
Type:
Small organic molecule
Emp. Form.:
C33H28N2O5S
Mol. Mass.:
564.651
SMILES:
COc1ccc(\C=C2/S\C(=N/c3ccccc3)N(Cc3ccc(cc3)C(O)=O)C2=O)cc1OCCc1ccccc1
Structure:
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