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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50445133
Substrate
n/a
Meas. Tech.
ChEMBL_1284449 (CHEMBL3106177)
Ki
0.002000±n/a nM
Citation
 Burger, MT; Han, W; Lan, J; Nishiguchi, G; Bellamacina, C; Lindval, M; Atallah, G; Ding, Y; Mathur, M; McBride, C; Beans, EL; Muller, K; Tamez, V; Zhang, Y; Huh, K; Feucht, P; Zavorotinskaya, T; Dai, Y; Holash, J; Castillo, J; Langowski, J; Wang, Y; Chen, MY; Garcia, PD Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors. ACS Med Chem Lett 4:1193-7 (2013) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50445133
Synonyms:
CHEMBL3103869
Type:
Small organic molecule
Emp. Form.:
C22H22F2N6O2
Mol. Mass.:
440.4459
SMILES:
N[C@@H]1CN(CC[C@H]1O)c1ccncc1NC(=O)c1nc(ccc1N)-c1c(F)cccc1F |r|
Structure:
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