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Target
P2Y purinoceptor 2
Ligand
BDBM50445214
Substrate
n/a
Meas. Tech.
ChEMBL_1284761 (CHEMBL3107658)
IC50
>10000±n/a nM
Citation
Qiao, JX; Wang, TC; Ruel, R; Thibeault, C; L'Heureux, A; Schumacher, WA; Spronk, SA; Hiebert, S; Bouthillier, G; Lloyd, J; Pi, Z; Schnur, DM; Abell, LM; Hua, J; Price, LA; Liu, E; Wu, Q; Steinbacher, TE; Bostwick, JS; Chang, M; Zheng, J; Gao, Q; Ma, B; McDonnell, PA; Huang, CS; Rehfuss, R; Wexler, RR; Lam, PY Conformationally constrained ortho-anilino diaryl ureas: discovery of 1-(2-(1'-neopentylspiro[indoline-3,4'-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a potent, selective, and bioavailable P2Y1 antagonist. J Med Chem 56:9275-95 (2013) [PubMed] Article
More Info.:
Target
Name:
P2Y purinoceptor 2
Synonyms:
ATP receptor | P2RU1 | P2RY2 | P2RY2_HUMAN | P2U purinoceptor 1 | P2U1 | P2Y purinoceptor 2 | P2Y2 | Purinergic receptor | Purinergic receptor P2Y2
Type:
PROTEIN
Mol. Mass.:
42299.21
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1455361
Residue:
377
Sequence:
MAADLGPWNDTINGTWDGDELGYRCRFNEDFKYVLLPVSYGVVCVPGLCLNAVALYIFLCRLKTWNASTTYMFHLAVSDALYAASLPLLVYYYARGDHWPFSTVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLRSLRWGRARYARRVAGAVWVLVLACQAPVLYFVTTSARGGRVTCHDTSAPELFSRFVAYSSVMLGLLFAVPFAVILVCYVLMARRLLKPAYGTSGGLPRAKRKSVRTIAVVLAVFALCFLPFHVTRTLYYSFRSLDLSCHTLNAINMAYKVTRPLASANSCLDPVLYFLAGQRLVRFARDAKPPTGPSPATPARRRLGLRRSDRTDMQRIEDVLGSSEDSRRTESTPAGSENTKDIRL