Reaction Details Report a problem with these data
Target
Kallikrein-5 [D153N]
Ligand
BDBM50446221
Substrate
n/a
Meas. Tech.
ChEMBL_1287999 (CHEMBL3110698)
Ki
400±n/a nM
Citation
 Oliveira, JP; Freitas, RF; Melo, LS; Barros, TG; Santos, JA; Juliano, MA; Pinheiro, S; Blaber, M; Juliano, L; Muri, EM; Puzer, L Isomannide-based peptidomimetics as inhibitors for human tissue kallikreins 5 and 7. ACS Med Chem Lett 5:128-32 (2014) [PubMed]  Article 
Target
Name:
Kallikrein-5 [D153N]
Synonyms:
KLK-L2 | KLK5 | KLK5_HUMAN | Kallikrein 5 | Kallikrein-5 | Kallikrein-like protein 2 | SCTE | Stratum corneum tryptic enzyme
Type:
PROTEIN
Mol. Mass.:
32031.75
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1282456
Residue:
293
Sequence:
MATARPPWMWVLCALITALLLGVTEHVLANNDVSCDHPSNTVPSGSNQDLGAGAGEDARSDDSSSRIINGSDCDMHTQPWQAALLLRPNQLYCGAVLVHPQWLLTAAHCRKKVFRVRLGHYSLSPVYESGQQMFQGVKSIPHPGYSHPGHSNNLMLIKLNRRIRPTKDVRPINVSSHCPSAGTKCLVSGWGTTKSPQVHFPKVLQCLNISVLSQKRCEDAYPRQIDDTMFCAGDKAGRDSCQGDSGGPVVCNGSLQGLVSWGDYPCARPNRPGVYTNLCKFTKWIQETIQANS
  
Inhibitor
Name:
BDBM50446221
Synonyms:
CHEMBL3109163
Type:
Small organic molecule
Emp. Form.:
C35H38N2O8
Mol. Mass.:
614.6848
SMILES:
O=C(O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)OCc1ccccc1)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)OCc1ccccc1 |r|
Structure:
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