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Target
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
Ligand
BDBM50447948
Substrate
n/a
Meas. Tech.
ChEMBL_1288598 (CHEMBL3119218)
IC50
680±n/a nM
Citation
 Nakao, S; Mabuchi, M; Shimizu, T; Itoh, Y; Takeuchi, Y; Ueda, M; Mizuno, H; Shigi, N; Ohshio, I; Jinguji, K; Ueda, Y; Yamamoto, M; Furukawa, T; Aoki, S; Tsujikawa, K; Tanaka, A Design and synthesis of prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors as anti-prostate cancer drugs. Bioorg Med Chem Lett 24:1071-4 (2014) [PubMed]  Article 
Target
Name:
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
Synonyms:
ABH3 | ALKB3_HUMAN | ALKBH3 | Alkylated DNA repair protein alkB homolog 3 | DEPC-1 | DEPC1 | Prostate cancer antigen 1
Type:
PROTEIN
Mol. Mass.:
33382.86
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108024
Residue:
286
Sequence:
MEEKRRRARVQGAWAAPVKSQAIAQPATTAKSHLHQKPGQTWKNKEHHLSDREFVFKEPQQVVRRAPEPRVIDREGVYEISLSPTGVSRVCLYPGFVDVKEADWILEQLCQDVPWKQRTGIREDITYQQPRLTAWYGELPYTYSRITMEPNPHWHPVLRTLKNRIEENTGHTFNSLLCNLYRNEKDSVDWHSDDEPSLGRCPIIASLSFGATRTFEMRKKPPPEENGDYTYVERVKIPLDHGTLLIMEGATQADWQHRVPKEYHSREPRVNLTFRTVYPDPRGAPW
  
Inhibitor
Name:
BDBM50447948
Synonyms:
CHEMBL3115013
Type:
Small organic molecule
Emp. Form.:
C20H20N4O2
Mol. Mass.:
348.3984
SMILES:
COc1ccc(Cc2c(C)[nH]n(-c3nc4ccc(C)cc4[nH]3)c2=O)cc1
Structure:
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