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Target
Beta-3 adrenergic receptor
Ligand
BDBM50448786
Substrate
n/a
Meas. Tech.
ChEMBL_1294758 (CHEMBL3128845)
EC50
0.190000±n/a nM
Citation
 Moyes, CR; Berger, R; Goble, SD; Harper, B; Shen, DM; Wang, L; Bansal, A; Brown, PN; Chen, AS; Dingley, KH; Di Salvo, J; Fitzmaurice, A; Gichuru, LN; Hurley, AL; Jochnowitz, N; Miller, RR; Mistry, S; Nagabukuro, H; Salituro, GM; Sanfiz, A; Stevenson, AS; Villa, K; Zamlynny, B; Struthers, M; Weber, AE; Edmondson, SD Design, synthesis, and evaluation of conformationally restricted acetanilides as potent and selectiveß3 adrenergic receptor agonists for the treatment of overactive bladder. J Med Chem 57:1437-53 (2014) [PubMed]  Article 
Target
Name:
Beta-3 adrenergic receptor
Synonyms:
ADRB3 | ADRB3_CANLF | B3AR
Type:
PROTEIN
Mol. Mass.:
43072.49
Organism:
Canis familiaris
Description:
ChEMBL_497812
Residue:
405
Sequence:
MAPWPHGNGSVASWPAAPTPTPDAANTSGLPGAPWAVALAGALLALEVLATVGGNLLVIVAIARTPRLQTMTNVFVTSLATADLVVGLLVVPPGATLALTGRWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRRARAAVVLVWVVSAAVSFAPIMSKWWRVGADAEAQRCHSNPHCCAFASNIPYALLSSSVSFYLPLLVMLFVYARVFLVATRQLRLLRRELGRFPPAESPPAASRSRSPGPARRCASPAAVPSDRLRPARLLPLREHRALRTLGLIVGTFTLCWLPFFVANVMRALGGPSLVPSPALLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCRREEHRAAASPPGDPSAAPAALTSPAESSRCQALDGASWGIS
  
Inhibitor
Name:
BDBM50448786
Synonyms:
CHEMBL3128194
Type:
Small organic molecule
Emp. Form.:
C25H28N4O2S
Mol. Mass.:
448.58
SMILES:
Nc1nc2[C@@H](CCc2s1)C(=O)Nc1ccc(C[C@@H]2CC[C@@H](N2)[C@H](O)c2ccccc2)cc1 |r|
Structure:
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