Target
Substance-P receptor
Ligand
BDBM50000257
Substrate
n/a
Meas. Tech.
ChEMBL_205901 (CHEMBL814485)
Ki
32±n/a nM
Citation
 Genicot, CChristophe, BCollart, PGillard, MGoossens, LHénichart, JPLassoie, MAMoureau, FNeuwels, MNicolas, JMPasau, PQuéré, LRyckmans, TStiernet, FTaverne, TVan Keulen, BJ Discovery of orally bioavailable NK1 receptor antagonists. Bioorg Med Chem Lett 13:437-42 (2003) [PubMed]  Article 
Target
Name:
Substance-P receptor
Synonyms:
NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46254.43
Organism:
Homo sapiens (Human)
Description:
P25103
Residue:
407
Sequence:
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
  
Inhibitor
Name:
BDBM50000257
Synonyms:
CHEMBL136187
Type:
Small organic molecule
Emp. Form.:
C25H26F6N2O
Mol. Mass.:
484.4772
SMILES:
FC(F)(F)c1cc(COCC(N2CCNCC2)c2ccc(C=C)c(C=C)c2)cc(c1)C(F)(F)F
Structure:
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