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Target
Substance-K receptor
Ligand
BDBM50002943
Substrate
n/a
Meas. Tech.
ChEMBL_448551 (CHEMBL897700)
Ki
1.00±n/a nM
Citation
 Sisto, A; Altamura, M; Cardinali, F; D'Andrea, P; Rossi, C; Fattori, D alpha,alpha-Cyclic aminoacids as useful scaffolds for the preparation of hNK(2) receptor antagonists. Bioorg Med Chem Lett 17:4841-4 (2007) [PubMed]  Article 
Target
Name:
Substance-K receptor
Synonyms:
NK-2 receptor | NK-2R | NK2R | NK2R_HUMAN | NKNAR | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | Neurokinin-2 (NK-2) | Neuromedin-2 receptor (NK-2R) | SKR | TAC2R | TACR2 | Tachykinin receptor 2 | Tachykinin receptor 2 (NK2) | hnk-3
Type:
Protein
Mol. Mass.:
44455.78
Organism:
Homo sapiens (Human)
Description:
P21452
Residue:
398
Sequence:
MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILAHRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATKCVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLRHLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMAGDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
  
Inhibitor
Name:
BDBM50002943
Synonyms:
CHEMBL394878
Type:
Small organic molecule
Emp. Form.:
C36H41N5O3S
Mol. Mass.:
623.807
SMILES:
CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCc3ccccc23)NC(=O)c2cc3ccccc3s2)CC1
Structure:
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