Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 1
Ligand
BDBM39344
Substrate
n/a
Meas. Tech.
ChEMBL_836135 (CHEMBL2077571)
IC50
12000±n/a nM
Citation
 Goralski, KB; Lou, G; Prowse, MT; Gorboulev, V; Volk, C; Koepsell, H; Sitar, DS The cation transporters rOCT1 and rOCT2 interact with bicarbonate but play only a minor role for amantadine uptake into rat renal proximal tubules. J Pharmacol Exp Ther 303:959-68 (2002) [PubMed]  Article 
Target
Name:
Solute carrier family 22 member 1
Synonyms:
Adrenaline alpha1 | Oct1 | Organic cation transporter 1 | S22A1_RAT | Slc22a1 | Solute carrier family 22 member 1 | adrenergic Alpha1 | rOCT1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
61538.40
Organism:
RAT
Description:
Adrenaline alpha1 0 RAT::Q63089
Residue:
556
Sequence:
MPTVDDVLEQVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTPGHYCQNPGVAELSQRCGWSQAEELNYTVPGLGPSDEASFLSQCMRYEVDWNQSTLDCVDPLSSLVANRSQLPLGPCEHGWVYDTPGSSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSVSGVLTAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQMAFTVGLVGLAGVAYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTRAVRIMEQIAQKNGKVPPADLKMLCLEEDASEKRSPSFADLFRTPNLRKHTVILMYLWFSCAVLYQGLIMHVGATGANLYLDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVTGAACLLMIFIPHELHWLNVTLACLGRMGATIVLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEVWQALPLILFGVLGLTAGAMTLLLPETKGVALPETIEEAENLGRRKSKAKENTIYLQVQTGKSSST
  
Inhibitor
Name:
BDBM39344
Synonyms:
4-amino-N-[2-(diethylamino)ethyl]benzamide;hydrochloride | 4-azanyl-N-[2-(diethylamino)ethyl]benzamide;hydrochloride | MLS000069436 | PROCAINAMIDE | PROCAINAMIDE HYDROCHLORIDE | SMR000059079 | cid_66068
Type:
Small organic molecule
Emp. Form.:
C13H21N3O
Mol. Mass.:
235.3253
SMILES:
CCN(CC)CCNC(=O)c1ccc(N)cc1
Structure:
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