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Target
Histamine H2 receptor
Ligand
BDBM50000411
Substrate
n/a
Meas. Tech.
ChEMBL_1333836 (CHEMBL3231654)
EC50
4600±n/a nM
Citation
 Bolhofer, WA; Hoffman, JM; Habecker, CN; Pietruszkiewicz, AM; Cragoe, EJ; Torchiana, ML Inhibition of gastric acid secretion by 1,8-naphthyridin-2(1H)-ones. J Med Chem 22:301-6 (1979) [PubMed]  Article 
Target
Name:
Histamine H2 receptor
Synonyms:
Gastric receptor I | H2R | HISTAMINE H2 | HRH2_RAT | Hrh2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40269.37
Organism:
RAT
Description:
HISTAMINE H2 HRH2 RAT::P25102
Residue:
358
Sequence:
MEPNGTVHSCCLDSMALKVTISVVLTTLILITIAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVLPFSAIYQLSFTWSFGHVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVAISLVFIWVISITLSFLSIHLGWNSRNGTRGGNDTFKCKVQVNEVYGLVDGLVTFYLPLLIMCVTYYRIFKIAREQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEAVEGIVLWLGYANSALNPILYAALNRDFRTAYQQLFHCKFASHNSHKTSLRLNNSLLPRSQSREGRWQEEKPLKLQVWSGTELTHPQGNPIR
  
Inhibitor
Name:
BDBM50000411
Synonyms:
CHEMBL3228809
Type:
Small organic molecule
Emp. Form.:
C18H27N3O
Mol. Mass.:
301.4265
SMILES:
CC(C)N(CCn1c2nc(C)cc(C)c2ccc1=O)C(C)C
Structure:
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