Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM50007652
Substrate
n/a
Meas. Tech.
ChEMBL_1339579 (CHEMBL3243059)
IC50
10.0±n/a nM
Citation
 Gonzalez, AZEksterowicz, JBartberger, MDBeck, HPCanon, JChen, AChow, DDuquette, JFox, BMFu, JHuang, XHouze, JBJin, LLi, YLi, ZLing, YLo, MCLong, AMMcGee, LRMcIntosh, JMcMinn, DLOliner, JDOsgood, TRew, YSaiki, AYShaffer, PWortman, SYakowec, PYan, XYe, QYu, DZhao, XZhou, JOlson, SHMedina, JCSun, D Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction. J Med Chem 57:2472-88 (2014) [PubMed]  Article 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM50007652
Synonyms:
CHEMBL3233134
Type:
Small organic molecule
Emp. Form.:
C24H28Cl2N2O6S
Mol. Mass.:
543.46
SMILES:
CC[C@@H](CS(=O)(=O)N(C)C)N1[C@@H]([C@H](O[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: