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Target
Protein kinase C delta type
Ligand
BDBM50187528
Substrate
n/a
Meas. Tech.
ChEMBL_1351519 (CHEMBL3268114)
Kd
2.5±n/a nM
Citation
 Pu, Y; Kang, JH; Sigano, DM; Peach, ML; Lewin, NE; Marquez, VE; Blumberg, PM Diacylglycerol lactones targeting the structural features that distinguish the atypical C1 domains of protein kinase C¿ and¿ from typical C1 domains. J Med Chem 57:3835-44 (2014) [PubMed]  Article 
Target
Name:
Protein kinase C delta type
Synonyms:
KPCD_MOUSE | Pkcd | Prkcd | Protein kinase C delta | Protein kinase C delta type | nPKC-delta
Type:
PROTEIN
Mol. Mass.:
77554.99
Organism:
Mus musculus
Description:
ChEMBL_1351519
Residue:
674
Sequence:
MAPFLRISFNSYELGSLQVEDEASQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKTTFDAHIYEGRVIQIVLMRAAEDPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMCVQYFLEDGDCKQSMRSEEEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKEFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTATNSRDTIFQKERFNIDMPHRFKVYNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRSSRKLDTTESVGIYQGFEKKPEVSGSDILDNNGTYGKIWEGSTRCTLENFTFQKVLGKGSFGKVLLAELKGKDKYFAIKCLKKDVVLIDDDVECTMVEKRVLALAWESPFLTHLICTFQTKDHLFFVMEFLNGGDLMFHIQDKGRFELYRATFYAAEIICGLQFLHSKGIIYRDLKLDNVMLDRDGHIKIADFGMCKENIFGEGRASTFCGTPDYIAPEILQGLKYSFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDIMEKLFERDPDKRLGVTGNIRIHPFFKTINWSLLEKRKVEPPFKPKVKSPSDYSNFDPEFLNEKPQLSFSDKNLIDSMDQEAFHGFSFVNPKFEQFLDI
  
Inhibitor
Name:
BDBM50187528
Synonyms:
(E)-{2-(hydroxymethyl)-4-[(3-hydroxyphenyl)methylene]-5-oxo-2,3-dihydrofur-2-yl}methyl 4-methyl-3-(methylethyl)pentanoate | CHEMBL206889
Type:
Small organic molecule
Emp. Form.:
C22H30O6
Mol. Mass.:
390.47
SMILES:
CC(C)C(CC(=O)OCC1(CO)C\C(=C/c2cccc(O)c2)C(=O)O1)C(C)C
Structure:
Search PDB for entries with ligand similarity: