Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50016462
Substrate
n/a
Meas. Tech.
ChEMBL_1347652 (CHEMBL3270691)
Ki
2.8±n/a nM
Citation
 Chen, J; Levant, B; Jiang, C; Keck, TM; Newman, AH; Wang, S Tranylcypromine substituted cis-hydroxycyclobutylnaphthamides as potent and selective dopamine D3 receptor antagonists. J Med Chem 57:4962-8 (2014) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50016462
Synonyms:
CHEMBL3265067
Type:
Small organic molecule
Emp. Form.:
C29H33ClN2O2
Mol. Mass.:
477.038
SMILES:
CCCN(CC[C@@]1(O)C[C@@H](C1)NC(=O)c1ccc2ccccc2c1)[C@@H]1C[C@H]1c1ccc(Cl)cc1 |r,wU:24.26,9.11,6.6,wD:26.30,(25.73,-55.68,;25.72,-54.14,;24.39,-53.38,;24.38,-51.84,;25.71,-51.06,;27.05,-51.83,;28.38,-51.05,;28.77,-52.53,;29.86,-51.45,;30.25,-49.96,;28.76,-49.56,;31.58,-49.18,;32.92,-49.94,;32.92,-51.48,;34.25,-49.17,;34.23,-47.63,;35.55,-46.85,;36.9,-47.62,;38.22,-46.84,;39.55,-47.6,;39.57,-49.14,;38.24,-49.92,;36.9,-49.16,;35.58,-49.94,;23.04,-51.08,;22.26,-49.74,;21.5,-51.09,;20.17,-51.86,;18.84,-51.1,;17.51,-51.87,;17.5,-53.41,;16.17,-54.18,;18.84,-54.18,;20.18,-53.41,)|
Structure:
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