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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50017007
Substrate
n/a
Meas. Tech.
ChEMBL_1364746 (CHEMBL3294007)
IC50
1.2±n/a nM
Citation
 Scott, JS; Goldberg, FW; Turnbull, AV Medicinal chemistry of inhibitors of 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1). J Med Chem 57:4466-86 (2014) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50017007
Synonyms:
CHEMBL3287026
Type:
Small organic molecule
Emp. Form.:
C23H31ClN2O4S
Mol. Mass.:
467.021
SMILES:
Cc1c(Cl)cccc1S(=O)(=O)N1CCCC[C@@H]1C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 |r,wU:20.21,wD:16.18,27.30,TLB:30:27:24:22.21.20,19:20:24:26.29.27,28:27:24:22.21.20,28:27:24.23.22:20,THB:29:23:20:26.27.30,29:27:24.23.22:20,30:21:24:26.29.27,(14.51,-15.82,;13.04,-16.3,;12.73,-17.8,;13.87,-18.83,;11.26,-18.28,;10.12,-17.25,;10.43,-15.75,;11.9,-15.27,;12.21,-13.76,;13.72,-14.08,;13.24,-12.61,;11.07,-12.73,;9.74,-13.5,;8.41,-12.74,;8.4,-11.2,;9.73,-10.43,;11.07,-11.2,;12.4,-10.43,;12.4,-8.89,;13.74,-11.19,;14.98,-10.31,;14.99,-8.89,;15.79,-10.28,;17.27,-10.8,;17.16,-12.34,;16.37,-10.8,;17.27,-9.73,;17.42,-8.31,;17.88,-6.85,;18.27,-9.68,;16,-7.79,)|
Structure:
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