Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM50018011
Substrate
n/a
Meas. Tech.
ChEMBL_1366448 (CHEMBL3296348)
IC50
18±n/a nM
Citation
 Deng, XKokkonda, SEl Mazouni, FWhite, JBurrows, JNKaminsky, WCharman, SAMatthews, DRathod, PKPhillips, MA Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors. J Med Chem 57:5381-94 (2014) [PubMed]  Article 
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
DHOdehase | Dhodh | Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial precursor | Dihydroorotate oxidase | PYRD_RAT
Type:
Enzyme
Mol. Mass.:
42672.97
Organism:
Rattus norvegicus (rat)
Description:
The enzyme assay was performed with the histidine-tagged enzyme without cleavage of the tag.
Residue:
395
Sequence:
MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR
  
Inhibitor
Name:
BDBM50018011
Synonyms:
Aubagio | CHEBI:68540 | HMR-1726 | TERIFLUNOMIDE
Type:
Small organic molecule
Emp. Form.:
C12H9F3N2O2
Mol. Mass.:
270.2073
SMILES:
C\C(O)=C(/C#N)C(=O)Nc1ccc(cc1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: