Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50064176
Substrate
n/a
Meas. Tech.
ChEMBL_1366833 (CHEMBL3297343)
Ki
27±n/a nM
Citation
Kolaczkowski, M; Marcinkowska, M; Bucki, A; Pawlowski, M; Mitka, K; Jaskowska, J; Kowalski, P; Kazek, G; Siwek, A; Wasik, A; Wesolowska, A; Mierzejewski, P; Bienkowski, P Novel arylsulfonamide derivatives with 5-HT6/5-HT7 receptor antagonism targeting behavioral and psychological symptoms of dementia. J Med Chem 57:4543-57 (2014) [PubMed] Article
More Info.:
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2
Type:
GPCR
Mol. Mass.:
51730.61
Organism:
Homo sapiens (Human)
Description:
P08172
Residue:
466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
Inhibitor
Name:
BDBM50064176
Synonyms:
CHEMBL27673 | CHEMBL500996 | METHOCTRAMINE | N,N''-Bis-[6-(2-methoxy-benzylamino)-hexyl]-octane-1,8-diamine | N1,N8-bis(6-(2-methoxybenzylamino)hexyl)octane-1,8-diamine
Type:
Small organic molecule
Emp. Form.:
C36H62N4O2
Mol. Mass.:
582.9031
SMILES:
COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC