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Target
Diacylglycerol O-acyltransferase 1
Ligand
BDBM50020049
Substrate
n/a
Meas. Tech.
ChEMBL_1363772 (CHEMBL3294189)
IC50
27±n/a nM
Citation
 Zhou, G; Zorn, N; Ting, P; Aslanian, R; Lin, M; Cook, J; Lachowicz, J; Lin, A; Smith, M; Hwa, J; van Heek, M; Walker, S Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors. ACS Med Chem Lett 5:544-9 (2014) [PubMed]  Article 
Target
Name:
Diacylglycerol O-acyltransferase 1
Synonyms:
DGAT1_MOUSE | Dgat | Dgat1 | Diacyl Glycerolacyltransferase 1 (DGAT-1) | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:
Enzyme
Mol. Mass.:
56810.61
Organism:
Mus musculus (mouse)
Description:
In this assay, recombinant mouse DGAT-1 containing an N-terminal His6-epitope tag was produced in the baculovirus expression system.
Residue:
498
Sequence:
MGDRGGAGSSRRRRTGSRVSVQGGSGPKVEEDEVRDAAVSPDLGAGGDAPAPAPAPAHTRDKDGRTSVGDGYWDLRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCVIIASNIFVVAAFQIEKRLAVGALTEQMGLLLHVVNLATIICFPAAVALLVESITPVGSVFALASYSIMFLKLYSYRDVNLWCRQRRVKAKAVSTGKKVSGAAAQQAVSYPDNLTYRDLYYFIFAPTLCYELNFPRSPRIRKRFLLRRVLEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWFFHSCLNAVAELLQFGDREFYRDWWNAESVTYFWQNWNIPVHKWCIRHFYKPMLRHGSSKWVARTGVFLTSAFFHEYLVSVPLRMFRLWAFTAMMAQVPLAWIVGRFFQGNYGNAAVWVTLIIGQPVAVLMYVHDYYVLNYDAPVGV
  
Inhibitor
Name:
BDBM50020049
Synonyms:
CHEMBL3287884
Type:
Small organic molecule
Emp. Form.:
C30H40N2O4
Mol. Mass.:
492.6496
SMILES:
CCCCCCCNC(=O)N1CCOc2cc(ccc12)-c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1 |r,wU:26.28,wD:29.32,(3.09,-11.07,;4.44,-11.81,;4.46,-13.35,;5.81,-14.1,;7.12,-13.31,;7.1,-11.77,;5.74,-11.03,;5.71,-9.5,;7.03,-8.7,;8.37,-9.43,;6.99,-7.16,;5.64,-6.41,;5.6,-4.87,;6.91,-4.07,;8.27,-4.81,;9.58,-4.01,;10.93,-4.75,;10.97,-6.3,;9.66,-7.1,;8.3,-6.36,;12.25,-3.95,;12.21,-2.41,;13.53,-1.61,;14.88,-2.35,;14.92,-3.89,;13.6,-4.7,;16.19,-1.55,;16.16,-.01,;17.47,.8,;18.83,.06,;20.14,.86,;20.1,2.4,;21.42,3.2,;18.75,3.14,;18.86,-1.49,;17.55,-2.29,)|
Structure:
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