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Target
Diacylglycerol O-acyltransferase 1
Ligand
BDBM50020078
Substrate
n/a
Meas. Tech.
ChEMBL_1363771 (CHEMBL3294188)
IC50
>10000±n/a nM
Citation
 Zhou, G; Zorn, N; Ting, P; Aslanian, R; Lin, M; Cook, J; Lachowicz, J; Lin, A; Smith, M; Hwa, J; van Heek, M; Walker, S Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors. ACS Med Chem Lett 5:544-9 (2014) [PubMed]  Article 
Target
Name:
Diacylglycerol O-acyltransferase 1
Synonyms:
ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:
Protein
Mol. Mass.:
55297.82
Organism:
Homo sapiens (Human)
Description:
O75907
Residue:
488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA
  
Inhibitor
Name:
BDBM50020078
Synonyms:
CHEMBL3287858
Type:
Small organic molecule
Emp. Form.:
C29H30N2O4
Mol. Mass.:
470.5595
SMILES:
OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1cccc2N(CCOc12)C(=O)Nc1ccccc1 |r,wU:7.10,wD:4.3,(19.28,3.4,;17.95,2.63,;16.62,3.4,;17.95,1.09,;16.62,.32,;15.28,1.09,;13.95,.32,;13.95,-1.22,;15.28,-1.99,;16.62,-1.22,;12.62,-1.99,;12.62,-3.53,;11.28,-4.3,;9.95,-3.53,;9.95,-1.99,;11.28,-1.22,;8.62,-4.3,;7.28,-3.53,;5.95,-4.3,;5.95,-5.84,;7.28,-6.61,;7.28,-8.15,;8.62,-8.92,;9.95,-8.15,;9.95,-6.61,;8.62,-5.84,;5.95,-8.92,;4.61,-8.15,;5.95,-10.46,;4.61,-11.23,;4.61,-12.77,;3.28,-13.54,;1.95,-12.77,;1.95,-11.23,;3.28,-10.46,)|
Structure:
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